Fundamental solution based numerical methods for three dimensional problems: efficient treatments of inhomogeneous terms and hypersingular integrals

In recent years, fundamental solution based numerical methods including the meshless method of fundamental solutions (MFS), the boundary element method (BEM) and the hybrid fundamental solution based finite element method (HFS-FEM) have become popular for solving complex engineering problems. The application of such fundamental solutions is capable of reducing computation requirements by simplifying the domain integral to the boundary integral for the homogeneous partial differential equations. The resulting weak formulations, which are of lower dimensions, are often more computationally competitive than conventional domain-type numerical methods such as the finite element method (FEM) and the finite difference method (FDM). In the case of inhomogeneous partial differential equations arising from transient problems or problems involving body forces, the domain integral related to the inhomogeneous solutions term will need to be integrated over the interior domain, which risks losing the competitive edge over the FEM or FDM. To overcome this, a particular treatment to the inhomogeneous term is needed in the solution procedure so that the integral equation can be defined for the boundary. In practice, particular solutions in approximated form are usually applied rather than the closed form solutions, due to their robustness and readiness. Moreover, special numerical treatment may be required when evaluating stress directly on the domain surface which may give rise to hypersingular integral formulation. This thesis will discuss how the MFS and the BEM can be applied to the three-dimensional elastic problems subjected to body forces by introducing the compactly supported radial basis functions in addition to the efficient treatment of hypersingular surface integrals. The present meshless approach with the MFS and the compactly supported radial basis functions is later extended to solve transient and coupled problems for three-dimensional porous media simulation

Traditional auriculotherapy for hypertension: a pilot randomized trial

Author name used in this publication: Lorna Kwai-ping Suen2013-2014 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Involvement of the nuclear high mobility group B1 peptides released from injured hepatocytes in murine hepatic fibrogenesis

AbstractThis study investigated the pro-fibrogenic role of high mobility group box 1 (HMGB1) peptides in liver fibrogenesis. An animal model of carbon tetrachloride (CCl4)-induced liver fibrosis was used to examine the serum HMGB1 levels and its intrahepatic distribution. The increased serum HMGB1 levels were positively correlated with elevation of transforming growth factor-β1 (TGF-β1) and collagen deposition during fibrogenesis. The cytoplasmic distribution of HMGB1 was noted in the parenchymal hepatocytes of fibrotic livers. In vitro studies confirmed that exposure to hydrogen peroxide and CCl4 induced an intracellular mobilization and extracellular release of nuclear HMGB1 peptides in clone-9 and primary hepatocytes, respectively. An uptake of exogenous HMGB1 by hepatic stellate cells (HSCs) T6 cells indicated a possible paracrine action of hepatocytes on HSCs. Moreover, HMGB1 dose-dependently stimulated HSC proliferation, up-regulated de novo synthesis of collagen type I and α-smooth muscle actin (α-SMA), and triggered Smad2 phosphorylation and its nuclear translocation through a TGF-β1-independent mechanism. Blockade with neutralizing antibodies and gene silencing demonstrated the involvement of the receptor for advanced glycation end-products (RAGE), but not toll-like receptor 4, in cellular uptake of HMGB1 and the HMGB1-mediated Smad2 and ERK1/2 phosphorylation as well as α-SMA up-regulation in HSC-T6 cells. Furthermore, anti-RAGE treatment significantly ameliorated CCl4-induced liver fibrosis. In conclusion, the nuclear HMGB1 peptides released from parenchymal hepatocytes during liver injuries may directly activate HSCs through stimulating HSC proliferation and transformation, eventually leading to the fibrotic changes of livers. Blockade of HMGB1/RAGE signaling cascade may constitute a therapeutic strategy for treatment of liver fibrosis

Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family — HSPL27

AbstractA novel cDNA clone was isolated from a human adult heart cDNA library. This cDNA clone is similar to the small heat shock protein (smhsp) in both DNA and amino acid sequences, especially in the conserved region. Sequence analysis has shown that the putative novel smhsp, named 27 kDa heat-shock-protein-like protein (HSPL27) is a protein of 241 amino acids with a deduced molecular mass of 26.7 kDa and a deduced pI of 8.0. We have expressed the HSPL27 in E. coli and the expressed protein was found to be present in the soluble fraction of the bacterial cell lysate. Chromosomal mapping data shows that the HSPL27 gene is located at human chromosome 5q11.2

Comparing the performance of published risk scores in Brugada syndrome: a multi-center cohort study.

The management of Brugada Syndrome (BrS) patients at intermediate risk of arrhythmic events remains controversial. The present study evaluated the predictive performance of different risk scores in an Asian BrS population and its intermediate risk subgroup. This retrospective cohort study included consecutive patients diagnosed with BrS from January 1 , 1997 to June 20 , 2020 from Hong Kong. The primary outcome is sustained ventricular tachyarrhythmias. Two novel risk risk scores and seven machine learning-based models (random survival forest, Ada boost classifier, Gaussian naïve Bayes, light gradient boosting machine, random forest classifier, gradient boosting classifier and decision tree classifier) were developed. The area under the receiver operator characteristic (ROC) curve (AUC) [95% confidence intervals] was compared between the different models. This study included 548 consecutive BrS patients (7% female, age at diagnosis: 50±16 years, follow-up: 84±55 months). For the whole cohort, the score developed by Sieira et al. showed the best performance (AUC: 0.806 [0.747-0.865]). A novel risk score was developed using the Sieira score and additional variables significant on univariable Cox regression (AUC: 0.855 [0.808-0.901]). A simpler score based on non-invasive results only showed a statistically comparable AUC (0.784 [0.724-0.845]), improved using random survival forests (AUC: 0.942 [0.913-0.964]). For the intermediate risk subgroup (N=274), a gradient boosting classifier model showed the best performance (AUC: 0.814 [0.791-0.832]). A simple risk score based on clinical and electrocardiographic variables showed a good performance for predicting VT/VF, improved using machine learning. Abstract: The management of Brugada Syndrome (BrS) patients at intermediate risk of arrhythmic events remains controversial. This study evaluated the predictive performance of published risk scores in a cohort of BrS patients from Hong Kong (N=548) and its intermediate risk subgroup (N=274). A novel risk score developed by modifying the best performing existing score (by. Sieira et al.) showed an area under the curve of 0.855 and 0.760 for the whole BrS cohort and the intermediate risk subgroup, respectively. The performance of the different scores was significantly improved machine learning-based methods, such as random survival forests and gradient boosting classifier. [Abstract copyright: Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Topological superfluid of spinless Fermi gases in p-band honeycomb optical lattices with on-site rotation

In this paper, we put forward to another route realizing topological superfluid (TS). In contrast to conventional method, spin-orbit coupling and external magnetic field are not requisite. Introducing an experimentally feasible technique called on-site rotation (OSR) into p-band honeycomb optical lattices for spinless Fermi gases and considering CDW and pairing on the same footing, we investigate the effects of OSR on superfluidity. The results suggest that when OSR is beyond a critical value, where CDW vanishes, the system transits from a normal superfluid (NS) with zero TKNN number to TS labeled by a non-zero TKNN number. In addition, phase transitions between different TS are also possible

Boundary and Coulomb Effects on Boson Systems in High-Energy Heavy-Ion Collisions

The boundary of a boson system plays an important role in determining the momentum distribution of the bosons. For a boson system with a cylindrical boundary, the momentum distribution is enhanced at high transverse momenta but suppressed at low transverse momenta, relative to a Bose-Einstein distribution. The boundary effects on systems of massless gluons and massive pions are studied. For gluons in a quark-gluon plasma, the presence of the boundary may modify the signals for the quark-gluon plasma. For pions in a pion system in heavy-ion collisions, Coulomb final-state interactions with the nuclear participants in the vicinity of the central rapidity region further modify the momentum distribution at low transverse momenta. By including both the boundary effect and the Coulomb final-state interactions we are able to account for the behavior of the $\pi^{-}$ transverse momentum spectrum observed in many heavy-ion experiments, notably at low transverse momenta.Comment: 15 pages Postscript uuencoded tar-comprssed file, 9 Postscript figures uuencoded tar-compressed fil